检索范围:
排序: 展示方式:
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 4-33 doi: 10.1007/s11705-021-2041-2
关键词: bioactive molecules fluorescent probes in living cells and in vivo review
Progress of three-dimensional macroporous bioactive glass for bone regeneration
Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU
《化学科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 470-483 doi: 10.1007/s11705-012-1217-1
关键词: bioactive glass biopolymer bone regeneration macroporous scaffolds tissue engineering
Development and clinical trial of a novel bioactive bone cement
LEONG John, LI Zhaoyang, LU William
《医学前沿(英文)》 2008年 第2卷 第2期 页码 117-126 doi: 10.1007/s11684-008-0022-1
关键词: bioactivity effectiveness strontium-containing hydroxyapatite osseointegration sufficient mechanical
NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis
Gang WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 1-7 doi: 10.1007/s11684-009-0018-5
关键词: free radicals tumor phox cell proliferation cancer therapy
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 37-44 doi: 10.1007/s11705-009-0294-2
关键词: development Polymorphism elucidation controversial relationship
Chemical transdifferentiation: closer to regenerative medicine
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 152-165 doi: 10.1007/s11684-016-0445-z
Cell transdifferentiation, which directly switches one type of differentiated cells into another cell type, is more advantageous than cell reprogramming to generate pluripotent cells and differentiate them into functional cells. This process is crucial in regenerative medicine. However, the cell-converting strategies, which mainly depend on the virus-mediated expression of exogenous genes, have clinical safety concerns. Small molecules with compelling advantages are a potential alternative in manipulating cell fate conversion. In this review, we briefly retrospect the nature of cell transdifferentiation and summarize the current developments in the research of small molecules in promoting cell conversion. Particularly, we focus on the complete chemical compound-induced cell transdifferentiation, which is closer to the clinical translation in cell therapy. Despite these achievements, the mechanisms underpinning chemical transdifferentiation remain largely unknown. More importantly, identifying drugs that induce resident cell conversion in vivo to repair damaged tissue remains to be the end-goal in current regenerative medicine.
关键词: cell therapy cell transdifferentiation chemical compounds small molecules tissue regeneration
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
《医学前沿(英文)》 2021年 第15卷 第2期 页码 292-301 doi: 10.1007/s11684-020-0806-5
关键词: bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
Emerging immunological strategies: recent advances and future directions
《医学前沿(英文)》 2021年 第15卷 第6期 页码 805-828 doi: 10.1007/s11684-021-0886-x
关键词: cancer immunotherapy bispecific antibodies small molecules chimeric antigen receptor T therapy cancer vaccines
《农业科学与工程前沿(英文)》 2022年 第9卷 第2期 页码 245-271 doi: 10.15302/J-FASE-2021439
Agricultural intensification and the subsequent decline of mixed farming systems has led to an increase in continuous cropping with only a few fallow or break years, undermining global soil health. Arable-ley rotations incorporating temporary pastures (leys) lasting 1–4 years may alleviate soil degradation by building soil fertility and improving soil structure. However, the majority of previous research on arable-ley rotations has utilized either grass or grass-clover leys within ungrazed systems. Multispecies leys, containing a mix of grasses, legumes, and herbs, are rapidly gaining popularity due to their promotion in agri-environment schemes and potential to deliver greater ecosystem services than conventional grass or grass-clover leys. Livestock grazing in arable-ley rotations may increase the economic resilience of these systems, despite limited research of the effects of multispecies leys on ruminant health and greenhouse gas emissions. This review aims to evaluate previous research on multispecies leys, highlighting areas for future research and the potential benefits and disbenefits on soil quality and livestock productivity. The botanical composition of multispecies leys is crucial, as legumes, deep rooted perennial plants (e.g., Onobrychis viciifolia and Cichorium intybus) and herbs (e.g., Plantago lanceolata) can increase soil carbon, improve soil structure, reduce nitrogen fertilizer requirements, and promote the recovery of soil fauna (e.g., earthworms) in degraded arable soils while delivering additional environmental benefits (e.g., biological nitrification inhibition and enteric methane reduction). Multispecies leys have the potential to deliver biologically driven regenerative agriculture, but more long-term research is needed to underpin evidence-based policy and farmer guidance.
中药生物活性成分对糖脂代谢紊乱疾病的治疗作用和机制 Review
张莹, 鞠佳明, 焦磊, 杨宝峰
《工程(英文)》 2023年 第29卷 第10期 页码 73-82 doi: 10.1016/j.eng.2023.03.004
胆固醇和葡萄糖稳态异常在心血管疾病、脑血管疾病、中枢神经系统疾病和癌症等多种疾病的发生发展中起着至关重要的作用。 越来越多的研究表明,体内脂肪堆积过多与2型糖尿病或胰岛素抵抗有关,高胆固醇和高血糖将加重上述疾病的发展进程。因此,稳定患者的血脂和血糖水平是改善心脑血管和中枢神经系统疾病患者症状的主要策略。中药(CHM)在中国已有两千多年的历史,建立了独特的中医理论,积累了丰富的临床经验。此外,中药在国内外广泛应用于心脑血管疾病的治疗和预防,具有防治高脂血症、糖尿病和高血压等疾病的优势。然而,中药在西方国家的使用仍然相当有限,部分原因是对其多种复杂成分的了解不完整,药理机制不确定。本文就中药生物活性成分及其制剂治疗高脂血症和高血糖症的作用、分子机制和临床研究进展进行综述和讨论。
关键词: Chinese herbal medicines Hyperlipidemia Hyperglycemia Cardiovascular and cerebrovascular diseases
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system
Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han
《医学前沿(英文)》 2020年 第14卷 第6期 页码 726-745 doi: 10.1007/s11684-020-0746-0
关键词: CAR T cells immunoregulatory molecules endogenous immune response solid malignancies
基于整合临床和动物实验的小分子筛选平台揭示经典方剂茵陈蒿汤治疗黄疸证显效状态下的活性化合物及潜在作用靶点 Article
熊辉, 张爱华, 郭雅静, 周小航, 孙晖, 杨乐, 方衡, 闫广利, 王喜军
《工程(英文)》 2021年 第7卷 第9期 页码 1293-1305 doi: 10.1016/j.eng.2020.12.016
中药方剂化学组成高度复杂,其药理作用具有多成分、多靶点的特点,使得阐明其生物活性化合物极具挑战性。茵陈蒿汤被广泛用于治疗黄疸相关疾病。尽管近年来茵陈蒿汤的药效及活性成分被不断证实,但仍然缺乏对其效应成分、效应机制和功能靶点的深入系统分析,尤其是临床研究方面。本研究建立了一个整合临床和动物实验平台用于发现茵陈蒿汤的活性化合物和潜在靶点。首先采用基于超高效液相色谱-四极杆飞行时间质谱(UPLC-Q-ToF-MS)技术的代谢组学方法结合中药血清药物化学方法揭示茵陈蒿汤的血清代谢谱和化学成分谱。此外,通过网络药理学和智能途径分析平台构建化合物-靶标-通路关联网络。最终发现茵陈蒿汤中8 个活性小分子与5 个核心靶点极度相关,并通过酶联免疫吸附测定实验进行生物学验证。结果表明茵陈蒿汤通过靶向胆固醇7α-羟化酶(CYP7A1)、多药耐药相关蛋白2(ABCC2)、多药耐药相关蛋白3(ABCC3)、尿苷二磷酸葡萄糖醛酸基转移酶1A1(UGT1A1)和法尼醇X受体(FXR)来调节包括初级胆汁酸生物合成、卟啉和叶绿素代谢以及胆汁分泌在内的代谢通路,从而发挥利胆退黄的作用。该整合策略可以成功地用于中药方剂活性小分子及其作用靶点的发现。
标题 作者 时间 类型 操作
Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
期刊论文
Progress of three-dimensional macroporous bioactive glass for bone regeneration
Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU
期刊论文
Development and clinical trial of a novel bioactive bone cement
LEONG John, LI Zhaoyang, LU William
期刊论文
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
期刊论文
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
期刊论文
AGRONOMIC AND ENVIRONMENTAL BENEFITS OF REINTRODUCING HERB- AND LEGUME-RICH MULTISPECIES LEYS INTO ARABLE ROTATIONS: A REVIEW
期刊论文
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system
Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han
期刊论文